Should the deployment of weapons of mass destruction ever be considered in a time of conflict when there can be significant non-combatant (civilian) casualties? What considerations should be made when thinking about those decisions? Is there differentiation across the inhabitants of a nation, its military, and its government?

Approach this question in the abstract, and not as specifically being about World War II or any related prior knowledge. It may be useful to create that sort of distance as you consider the issues around such decisions. 

Please be mindful and respectful of the language that you use when considering this topic.

One paragraph 150 to 250 words