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Explain what happens physiologically with chronic renal failure and the GFR

Initial Post: Explain what happens physiologically with chronic renal failure and the GFR. Support with evidence. Include important labs that are monitored in the process.
Response #1: Explain the role of Angiotensin II and proteinuria as they relate to advancing renal disease.
Response #2: List at least three other body systems that are impacted by chronic kidney disease and why.

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