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Hand hygiene initiative: comparative study of pre- and postintervention outcomes Mohammed Fouad1,2 and Sheref Eltaher3,4

1Microbiology and Immunology Department, Faculty of Medicine, Benha University, Benha, Egypt. 2Public Health Department, Health Sciences College at Al Leith, Umm Al-Qura University, Saudi Arabia. 3Department of Family Medicine and Community Medicine, Faculty of Medicine, Taibah University, Taibah, Saudi Arabia. 4Department of Public Health and Community Medicine, Faculty of Medicine, Benha University, Benha, Egypt (Corre- spondence to: Sheref Eltaher: [email protected]).

Abstract Background: Adequate hand hygiene is considered the most effective measure to reduce transmission of nosocomial pathogens. Aims: To determine the effectiveness of infection control intervention to improve compliance with hand hygiene in the Emergency Department, Al-Leith General Hospital, Saudi Arabia, and evaluate bacterial load on hands as a possible indi- cator of improvement. Methods: The study consisted of 3 phases: Phase I, measurement of basal hand hygiene compliance level; Phase II, mul- timodal hand hygiene educational programme was initiated; and Phase III, hand hygiene compliance level was measured again. Data were collected by direct observation of healthcare workers in the emergency department between October 2016 and March 2017, using the standardized World Health Organization method for direct observation, “Five Moments for Hand Hygiene”. The intervention comprised health education sessions using direct personal contact. Hands of health- care workers were sampled during Phases I and III by sterile bag method, and bacterial load was determined. Results: A total of 1374 opportunities for hand hygiene were observed during the triphase study. Implementation of the in- terventional hand hygiene educational programme significantly improved compliance with hand hygiene guidelines from 30.7% to 45.5% (P < 0.01). Log10 bacterial load per hand dropped from 4.97 (standard deviation = 0.32) to 4.57 (0.47) (P < 0.05). Conclusions: Hand hygiene educational programmes were effective in improving compliance in the emergency depart- ment, and bacterial load on hands of healthcare workers could be used as an indicator of improvement in hand hygiene compliance. Keywords: bacterial load, compliance, Five Moments for Hand Hygiene, hand hygiene, infection Citation: Fouad M; Eltaher S. Hand hygiene initiative: comparative study of pre- and post-intervention outcomes. East Mediterr Health J. 2020;26(2):198–205. https://doi.org/10.26719/2020.26.2.198 Received: 10/01/18; accepted: 11/07/18 Copyright © World Health Organization (WHO) 2020. Open Access. Some rights reserved. This work is available under the CC BY-NC-SA 3.0 IGO license (https://creativecommons.org/licenses/by-nc-sa/3.0/igo).

Introduction Healthcare-associated infections (HAIs) are acquired dur- ing treatment for another condition and are not present or incubating at the time of admission, and they carry a significant burden of illness and financial costs (1). Ap- proximately 7% of hospitalized patients in industrialized nations and 10% in low- and middle-income countries are affected (2).

Hand hygiene is among the most important measures to prevent transmission and acquisition of HAIs (3). Despite recognition of the crucial role of hand hygiene in reducing infection rates, compliance rates among healthcare workers remain low (4). In a systematic review of 96 studies from industrialized nations, the overall average compliance was 40% (5).

According to the World Health Organization (WHO) the multimodal “Clean Care Is Safer Care” strategy and the “Five Moments for Hand Hygiene” concept should be performed (1) before touching a patient; (2) before aseptic procedures; (3) after risk of body fluid exposure; (4)

after touching a patient; and (5) after touching patients’ surroundings (6,7).

The emergency department has special environmental conditions that may interfere with proper hand hygiene compliance, including crowding, use of nontraditional care areas such as hallways, frequent interruptions to care delivery, and close proximity of patients, who are often separated only by curtains (8,9). Few other studies have assessed the efficacy of hand hygiene interventions in emergency departments (10–13), and yet fewer have used the WHO “Five Moments for Hand Hygiene”. Other studies have used alternative methods (9). Due to the rapid turnover in emergency departments, it is difficult to measure HAI rates as an indicator of improvement. HAIs, by definition, develop after at least 48 hours of hospitalization, and most emergency cases are discharged on the same day.

The aim of this study was to determine the effectiveness of infection control intervention to improve compliance with hand hygiene in the Emergency Department, Al-Leith General Hospital, Saudi Arabia.

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We also evaluated bacterial load on hands as a possible indicator of improvement of hand hygiene compliance.

Methods Study setting The study was conducted in the Emergency Department at Al-Leith General Hospital, Saudi Arabia, between October 2016 and March 2017. Al-Leith General Hospital is a sec- ondary level hospital with a total capacity of 65 beds. This work was approved by the Bioethics Committee, Health Sciences College at Alith, Umm Al-Qura University.

Study design This was an interventional study that consisted of 3 phas- es: Phase I, the basal hand hygiene compliance level was measured by direct observation; Phase II, a hand hygiene educational programme was offered to healthcare staff working in the hospital emergency department; and Phase III, hand hygiene compliance level was measured again to determine the effect of the intervention.

Observations and calculations Data were obtained from 40 observation sessions; 20 in Phase I and 20 in Phase III. Each observational session was ~20 minutes. The timings of the observation ses- sions were randomly distributed throughout the day and night. Observations were conducted by trained volunteer students. All professional healthcare providers and stu- dents who were working in the emergency department were included in the study. Healthcare workers were divided into 3 professional categories: (1) nurse/nurse student; (2) medical doctor/medical student; and (3) oth- er healthcare workers (therapists/technicians/dietitians/ dentists/students).

Counting of hand hygiene opportunities and hand hygiene actions was based on the WHO Five Moments of Hand Hygiene concept: (1) before touching a patient; (2) before clean/aseptic procedure; (3) after risk of body fluid exposure; (4) after touching a patient; and (5) after touching patients’ surroundings (6,14,15).

A hand hygiene opportunity is defined as a moment during healthcare activities when hand hygiene is required, regardless of the number of indications. Several indications may arise simultaneously, creating a single opportunity and requiring a single hand hygiene action (15). Accepted hand hygiene actions include healthcare workers performing alcohol-based hand rubbing or handwashing with soap and water. Hand hygiene compliance was calculated by dividing the number of performed hand disinfections by the number of hand hygiene opportunities. Analyses were stratified by professional group.

Compliance (%)= ×100Actions Opportunities

Training of auditors In October 2016, volunteer students were recruited as

hand hygiene auditors after a detailed training process. Training included prepared PowerPoint presentations and educational video of actual healthcare workers per- forming patient care tasks (16). During video watching, the students were asked to observe and report hand hy- giene opportunities and actions using the actual observa- tion form that would be used in the study. Later, students were engaged in inter-rater reliability testing, in which a series of hand hygiene practices were co-observed in the emergency department, and disagreements were discussed and resolved according to WHO hand hygiene training tools (16).

Phase I (preintervention: November–December 2016) Phase I is referred to as baseline assessment. Hand hy- giene compliance rate in the emergency department was determined for the above-mentioned Five Moments of Hand Hygiene by trained assessors. Potential opportuni- ties for hand hygiene were recorded along with the actual number of episodes of hand hygiene. Recording was per- formed on a special observation form. Observations were done at random times without prior announcement. Ob- servers acted as unobtrusively as possible but disclosed their task readily on enquiry. Observation sessions lasted 20 (5) minutes.

Phase II (intervention: January 2017) Phase II was the interventional phase. This was a mul- timodal intervention that was conducted in the form of health education sessions using direct personal contact by volunteer students; educational lectures that included a live demonstration of hand hygiene techniques; posters that demonstrated the Five Moments of Hand Hygiene; and other posters that emphasized the importance of hand hygiene (e.g., Hand Hygiene Saves Lives). The post- ers were placed at strategic sites within the emergency department, ensuring availability of alcohol-based hand cleaners and personal protective equipment at all patient care areas. An additional component of the intervention was feedback, which consisted of announcing the com- pliance results from Phase I to the emergency depart- ment staff.

Phase III (postintervention: February–March 2017) After the educational interventions, hand hygiene com- pliance was measured again using the same methods fol- lowed in Phase I.

Determining hand bacterial load It is difficult to monitor HAI rates among emergency de- partment patients because of the short stays involved. Therefore, we introduced measurement of bacterial load on hands of healthcare workers as an alternative to measure the benefit obtained by improvement in hand hygiene compliance rates. Fifty samples were taken from hands of healthcare workers during Phase I, and another 50 samples were taken during Phase III. Samples were

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taken from the dominant hand in both phases because hand microbiomes differ between dominant and non- dominant hands (17). The sampling method was a mod- ified sterile bag adopted from the method used by Lar- son et al. (18). Sterile peptone water (50 ml) was poured into sterile polyethylene bags, after which, the hand of the healthcare worker was inserted, the bag opening was secured at the wrist with a tourniquet, and the hand was uniformly massaged for 1 minute by the research staff through the wall of the bag. The solution was mixed in the bag and 0.05-ml aliquots of each sampling solution were plated on tryptic soy agar plates (Merck, Darmstadt, Germany). Inocula were spread with bent glass rods. Plates were incubated at 37°C under aerobic conditions for 24 hours, and colony-forming units (CFU) were counted, and bacterial load was calculated and expressed as CFU/hand. Bacterial load on hands was compared us- ing the log10-transformed bacterial count.

Statistical analysis The data were tabulated, coded and analysed using SPSS for Windows version 20.0. Compliance rates at baseline and follow-up, overall, for the different professional cat- egories, and for different hand hygiene indications were compared using the χ2 test. Paired t test was done to test the significance of the difference in mean CFU counts be- tween Phases I and III. P < 0.05 was considered significant.

Results There were 1374 hand hygiene opportunities during the study. Nurses had the largest number of opportunities (87.92%) in comparison to other professional groups (Table 1). Profession-specific analysis revealed that hand hygiene compliance increased significantly in physicians (187% of baseline) and nurses (147% of baseline) (both P < 0.01). The compliance of the other healthcare workers can be consid- ered unchanged since the variation was insignificant (P = 0.926). The total number of hand hygiene actions sig- nificantly increased from 203/662 (30.66%) in Phase I to 324/712 (45.51%) in Phase III (P < 0.01) (Table 2).

Compliance results revealed that indication-specific differences ranged from 12.21% (Indication 2) to 48.84% (Indication 4) at baseline (Tables 3 and 4). Compliance before patient contact and before aseptic tasks (Indications 1 and 2) was lower compared to that after patient contact (Indications 3–5). Significant improvements were seen only for Indications 1, 2 and 5. The greatest improvement was seen for Indication 2 (279% of baseline; P < 0.01), and the lowest for Indication 5 (137% of baseline; P = 0.018).

Bacterial load on hands of healthcare workers was measured in Phases I and III (Figure 1). In phase I before intervention average log CFU/hand was 4.97 (0.32). In Phase III log CFU/hand was significantly increased to 4.57 (0.47) (P < 0.001).

Discussion The emergency department is an indispensable compo- nent of the current healthcare system; nevertheless, it may have special environmental conditions that inter- fere with proper hand hygiene compliance. Although there have been many interventional studies of hand hy- giene, published data from Saudi Arabia are limited and show contradicting results (19,20). Hand hygiene among healthcare workers remains low and there is room for im- provement.

In this study, the educational intervention was associated with a significant increase in compliance rate (30.66 to 45.51%). This result is similar to previous studies showing that educational interventions improve hand hygiene compliance (21,22). A few studies have reported hand hygiene compliance rates in Saudi Arabia (13,19,20, 23,24). Our pre- and postintervention compliance rates (30.66% and 45.51%, respectively) are inferior to an overall compliance rate of 50.3% reported previously in Saudi Arabia (13). The lower rate in our study may have been because it was conducted in the emergency department, which had unique environmental conditions that impeded proper application of hand hygiene. In another study conducted in Saudi Arabia, the compliance rate was 62.5% (19) but the method of calculation was based on classifying healthcare workers as compliant or noncompliant, which is a flawed method, because compliance varies in the same person over time. The international consensus is to measure compliance per opportunity rather than per person. A third study conducted in intensive care units in a Saudi hospital reported a compliance rate of 59% (23). In a systematic review of 96 studies on hand hygiene, compliance levels in non-intensive care settings were 50–60% (5), which is superior to the levels obtained in our study. The relatively low level of postintervention compliance (45.5%) is comparable to that in other studies performed in the emergency department. This was evident in a study performed in emergency departments where compliance reached 45% after 2 successive interventions (21).

The relatively low hand hygiene compliance rate in this study (<50%) could be attributed to laxity of the pre-existing infection control programme in the study hospital. For example, essential infection control activities

Table 1 Hand hygiene opportunities according to health care worker professional group

Professional group

Phase I Phase III Total

n % n % n % Nurses 582 87.92 566 79.49 1148 83.55

Physicians 71 10.73 127 17.84 198 14.41

Other 9 1.36 19 2.67 28 2.04

Total 662 100.0 712 100.0 1374 100.0

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such as surveillance and auditing were performed irregularly and were merely performed as paperwork. It could also be attributed to the special characteristics of the study settings in the emergency department, as mentioned before. The absence of leadership engagement in this study could also have been partially responsible for the modest improvement. Effective leadership involvement can improve hand hygiene compliance (25,26). Continuing efforts and further interventions are needed to address such issues.

Our results show that physicians had less compliance for hand hygiene than nurses had (23.9% vs 31.4% in Phase I, respectively). This result is in accordance with other local and international studies (13,27). Previous studies have shown that physicians in general show poor compliance with infection control standards (28). This was evident in a study conducted in Saudi Arabia in which adherence rates were reported as 60% for nurses and 20% for physicians at the completion of a hand hygiene improvement campaign (13). It is noticeable that although physicians’ compliance level was inferior to that of nurses, they showed a higher level of improvement in Phase III.

Our study showed that most hand hygiene opportunities were encountered by nurses (1148/1374; 83.6%). This represents an opportunity to target nurses by tailored educational programmes to foster hand hygiene compliance improvements among such an influential

group. It has been shown that the level of knowledge and compliance with hand hygiene practice differs significantly among nurses according to years of service; the highest level of knowledge was achieved by nurses with < 1 year of service, while the highest compliance level was achieved by more experienced nurses (16–20 years of service). The same study showed that higher levels of nurse education (receiving post-basic course) was associated with increased hand hygiene compliance (29). These finding reflects that hand hygiene education should be continuous and target not only newly recruited nurses, but also those with more experience. Other strategies, beside nurse education, that were proved to positively influence hand hygiene compliance include those aimed at social influence within teams and enhanced leadership (30).

Although hand hygiene compliance levels improved in physicians and nurses, there was no significant change in the other groups, which included technicians, therapists and radiologists. However, the number of observed opportunities for this group in Phase I was relatively small, which was reflected in their statistical results. The compliance rate in this group could also have been affected by the difficulty in targeting such a group in educational activities, which were held using a variety of methods, but mainly by interpersonal communication in the emergency department. Therefore, we can speculate that the chance of receiving an educational session is increased by the average period spent by the personnel in the emergency department. Educational and motivational programmes adapted to specific groups of health personnel are needed to address such a situation.

In this study, the compliance rate before patient contact (23.93%) was lower than after patient contact (48.84%). Similar results have been reported in other local (23) and international (21) studies. This is a phenomenon worth mentioning, because, paradoxically, situations that pose more risk of infection to patients are associated with less hand hygiene compliance from healthcare workers. Hand hygiene before patient contact and before aseptic tasks (Indications 1 and 2) plays a major role in controlling HAIs and avoiding cross-transmission of multiresistant bacteria, thus compliance with these 2 indications is a cornerstone in infection control (6). These 2 indications also showed the highest percentage of improvement after intervention; Indication 2, in particular, showed

Table 2 Hand hygiene compliance rates according to professional group

Professional group

Phase I Phase III Total P*

Opportunities HH Action

Compliance (%)

Opportunities HH Action

Compliance (%)

Nurses 582 183 31.44 566 261 46.11 < 0.001

Physicians 71 17 23.94 127 57 44.88 0.004

Other 9 3 33.33 19 6 31.58 0.926

Total 662a 203 30.66 712 324 45.51 < 0.001 *Calculated by χ2 test. aSum of indications is not equal to the sum of opportunities because 1 opportunity may cover 2 overlapping indications.

Table 3 Hand hygiene opportunities according to WHO Five Moments for Hand Hygiene

Hand hygiene encounter

Phase I Phase III

n % n % 1. Before touching a

patient 117 17.38 116 16.11

2. Before aseptic procedures

172 25.56 217 30.14

3. After body fluid exposure risk

87 12.93 106 14.72

4. After touching a patient

172 25.56 137 19.03

5. After touching patient surroundings

125 18.57 144 20.00

Total 673a 100.0 720 100.0 aNumber of opportunities according to Five Moments for Hand Hygiene is larger than according to healthcare worker professional group due to the fact that an opportunity may be counted twice for 2 indications and once for 1 HCW if 2 indications overlapped.

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more than double improvement (12.21% to 34.1%). The ignorance of Indication 2 (before aseptic procedure) may have been due to an incorrect assumption that performing hand hygiene before patient contact was enough, and this misconception could be corrected by administering proper hand hygiene education.

The difficulty in targeting particular groups of health personnel, the need to improve the modest adherence to hand hygiene in emergency departments, as well as the need to achieve sustainable improvement, all impose challenging demands on healthcare organizations to develop and maintain an innovative and multidisciplinary approach to improve adherence to hand hygiene. Successful and sustained hand hygiene improvement can be achieved by implementing multiple actions to tackle different obstacles and behavioural barriers. WHO has proposed a multimodal strategy that includes 5 key components: (1) supportive infrastructure; (2) training and education; (3) evaluation and feedback; (4) reminders in the workplace; and (5) creating an institutional safety awareness climate (31). All these elements were implemented in the present study.

Suggestions for further improvements to be implemented include patient participation and leadership involvement. These components were missing from the current study. Patient participation has been shown to be effective in improving compliance (32) and is increasingly recognized as an important item to be included in multimodal strategies to improve hand hygiene adherence (33). Leadership involvement was also absent from our study. Absence of leadership has been linked with loss of sustainable change in hand hygiene compliance (34). Other studies have shown that inclusion of administrative leadership is linked with improvements in hand hygiene compliance rates and most importantly with enhanced sustainability of such improvements (25, 26).

Measurement of HAI rates as an indicator of improved hand hygiene in emergency departments is difficult due to rapid patient turnover rate. This study attempted to evaluate bacterial hand load as an indicator of improvement after infection control intervention. It has

been demonstrated previously that there are significant differences in mean CFU counts before and after handwashing according to frequency of hand washing; bacterial counts tend to decrease with increasing frequency of hand washing (35). We tried to use bacterial load on healthcare workers’ hands as an indirect indicator of overall hand hygiene compliance. The average bacterial load per hand decreased significantly, which suggests that average bacterial load on hands of healthcare workers can be used as an objective measurement for overall hand hygiene compliance. Although bacterial load count tends to show great variability from person to person and from time to time, we showed that change in the average count may be used as an indicator for overall compliance. It is difficult to prove the validity of this method due to natural variability of bacterial count

Table 4 Indication specific hand hygiene compliance rates according to the WHO Five Moments for Hand Hygiene

Hand hygiene indication

Phase I Phase III P*

Opportunities HH Action

Compliance (%)

Opportunities HH Action

Compliance (%)

1. Before touching a patient

117 28 23.93 116 53 45.69 < 0.001

2. Before aseptic procedures

172 21 12.21 217 74 34.10 0.004

3. After body fluid exposure risk

87 27 31.03 106 43 40.57 0.926

4. After touching a patient

172 84 48.84 137 81 59.12 < 0.001

5. After touching patient surroundings

125 48 38.40 144 76 52.78 0.02

*Calculated by χ2 test.

Lo g

CF U

p er

h an

d

6.0

5.5

5.0

4.5

4.0

Phase

3.5

3.0

Phase I Phase III

60

74

Figure 1 Box and whisker plots showing bacterial load on hands of healthcare workers measured during Phases I and III.

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مبادرة نظافة األيدي: دراسة مقارنة للمخرجات قبل التدخل وبعده حممد فؤاد، رشيف الطاهر

اخلالصة اخللفية: ُتعد نظافة األيدي الكافية أكثر التدابري فعالية للحد من انتقال اجلراثيم املستشفوية.

األهداف: حتديد مدى فعالية التدخل بشأن مكافحة العدوى لتحسني االلتزام بنظافة األيدي يف قسم الطوارئ، بمستشفى الليث العام، يف اململكة العربية السعودية، وحتديد كمية اجلراثيم عىل األيدي بوصفها مؤرشًا حمتماًل ملستوى التحسن.

طرق البحث: تكونت الدراسة من 3 مراحل: املرحلة األوىل: قياس املستوى القاعدي لاللتزام بنظافة األيدي؛ واملرحلة الثانية: بدء تنفيذ برنامج تثقيفي متعدد النامذج حول نظافة األيدي؛ واملرحلة الثالثة: قياس مستوى نظافة األيدي جمددًا. وُجعت البيانات من خالل املالحظة املبارشة للعاملني يف جمال الرعاية الصحية يف قسم الطوا&#

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