Anti-inflammatory drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, are widely used for managing various inflammatory conditions. Discuss the potential challenges and considerations a Nurse Practitioner might face when initiating and monitoring therapy with these medications. Consider factors such as the patient's renal function, gastrointestinal risk, potential drug-drug interactions, and contraindications to therapy. How can a Nurse Practitioner manage these challenges to ensure the safe and effective use of anti-inflammatory drugs in their patients?